Article

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle

2026-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Exercise induces extensive, cell–type–specific transcriptional remodeling in skeletal muscle to support metabolic flexibility and adaptation. However, the regulatory mechanisms underlying these transcriptional programs, and the extent to which they differ between sexes, remain poorly defined. We previously reported that lifelong, muscle-specific overexpression of human Transcription Factor E-B (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14b5f954-7946-5590-a53d-afcbaa5fee8f
DOI: 10.64898/2026.01.23.700915

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscleDOI 10.64898/2026.01.23.700915Read

Transcriptional Diversity in Response to Aging Across Skeletal MusclesSemantic proximity Read

Temporal dynamics of the multi-omic response to endurance exercise training across tissuesSemantic proximity Read

Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength trainingSemantic proximity Read

Sex-specific signatures of brain-wide induction of ΔFOSB and altered co-activation networks in a mouse model for exercise trainingSemantic proximity Read

Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance TrainingSemantic proximity Read

A muscle exercise research revolution powered by -omics at single cell and nucleus resolutionSemantic proximity Read

Extensive differential gene expression and regulation by sex in human skeletal muscleSemantic proximity Read

Combined aerobic and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adultsSemantic proximity Read

Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung—Findings from MoTrPACSemantic proximity Read

Single-nucleus RNA sequencing reveals cellular and molecular dynamics of white and brown adipose tissue in a mouse model of type-2 diabetesSemantic proximity Read

Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exerciseSemantic proximity Read

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal diseaseSemantic proximity Read