Article

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication

2026-03-04

Abstract excerpt

Mitochondrial structural plasticity is a critical adaptive response to cellular stress, yet the transcriptional networks governing the formation of specialized mitochondrial architectures remain poorly defined. Here, we identified and demonstrated that activating transcription factor 4 (ATF4), the master regulator of the integrated stress response, directly regulates mitochondrial morphological remodeling through...

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Literature Corpus work: 35529c73-6524-5167-8e7f-f4106a1c3d81
DOI: 10.64898/2026.03.04.709625

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