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Article

Transcriptional Diversity in Response to Aging Across Skeletal Muscles

9 Jul 2025

Abstract excerpt

Aging leads to a gradual decline in muscle function, yet the mechanisms by which different skeletal muscles respond to aging remain unclear. Here, we constructed transcriptional maps of 11 skeletal muscles with extensive transcriptional diversity from young and old mice. Age-related changes in gene expression displayed distinct tissue-specific patterns, involving muscle diseases and metabolic processes. Notably,...

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PMID: 40631796
DOI: 10.1111/acel.70164

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