Article

Cell-type-specific ATF6α programs regulate epithelial mitochondrial homeostasis and pericyte remodeling during physiological and exposure-accelerated lung aging

2026-07-10

Abstract excerpt

Proteostasis declines with lung aging, while the role of the Unfolded Protein Response (UPR) in lung aging and age–associated pulmonary diseases remains understudied. We investigated how deficiency in the UPR sensor ATF6α affects physiological and smoke exposure–accelerated lung aging. ATF6α –deficient mice exhibited accelerated alveolar simplification, a sign of lung parenchymal aging, which was exacerbated by sm...

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Literature Corpus work: 4cb943a3-c0ac-5497-b3e8-811605ada02f
DOI: 10.64898/2026.07.09.737329

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Cell-type-specific ATF6α programs regulate epithelial mitochondrial homeostasis and pericyte remodeling during physiological and exposure-accelerated lung agingDOI 10.64898/2026.07.09.737329Read

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