Article

Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcription

2022-07-25

Abstract excerpt

A causative role for DNA damage as a molecular driver of aging has long been advocated. Transcription-blocking lesions (TBLs) accumulate with age in a stochastic manner. Thus, gene expression data might reflect the gene length-dependent accumulation of TBLs. Here we present an analysis of gene expression as a function of gene length in several independent single-cell RNA sequencing datasets of mouse and human agin...

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Literature Corpus work: 2eb4e070-a690-5b27-b660-76d026ddb81f
DOI: 10.1101/2022.07.22.501099

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