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Article

Gene length matters in neurons.

Neuron - 22 Apr 2015

Zylka Mark J, Simon Jeremy M, Philpot Benjamin D

Abstract excerpt

A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and tra...

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Identifiers

PMID: 25905808
DOI: 10.1016/j.neuron.2015.03.059
PMCID: PMC4584405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25905808-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Gene length matters in neurons.PMID 25905808Read ↗

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.Semantic proximity Read ↗

Non-CG DNA methylation and MeCP2 stabilize repeated tuning of long genes that distinguish closely related neuron typesSemantic proximity Read ↗

Bias toward long gene misregulation in synaptic disorders can be an artefact of amplification-based methodsSemantic proximity Read ↗

DNA methylation in the gene body influences MeCP2-mediated gene repression.Semantic proximity Read ↗

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesisSemantic proximity Read ↗

MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes.Semantic proximity Read ↗

MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal GenesSemantic proximity Read ↗

MeCP2 represses the activity of topoisomerase IIβ in long neuronal genesSemantic proximity Read ↗

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.Semantic proximity Read ↗

Gene size matters: What determines gene length in the human genome?Semantic proximity Read ↗

Role of gene length in control of human gene expression: chromosome-specific and tissue-specific effectsSemantic proximity Read ↗

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome modelsSemantic proximity Read ↗

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