MECP2pedia: A Comprehensive Transcriptome Portal for MECP2 Disease Research

Abstract excerpt

<h4>Summary</h4> Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2s molecular role. Focusing on individual transcriptomic studies yields inconsistent differentially expressed genes. We have aggregated and homogeneously processed modern public MeCP2 transcriptome data, which we present in a web portal. With this big data, we discovered a commonly perturbed core set...

Topics

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• Brain-Derived Neurotrophic Factor
• Disease Models, Animal
• Gene Expression Profiling
• Methyl-CpG-Binding Protein 2
• Mice
• Mutation
• Rett Syndrome
• Transcriptome

Identifiers and source

Literature Corpus work

04832ae5-2ce8-5636-9649-9cc65e6a0056

DOI

10.1101/2021.11.27.470197