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Article

Leveraging local ancestry to detect gene-gene interactions in genome-wide data.

BMC genetics - 24 Oct 2015

Aschard Hugues, Gusev Alexander, Brown Robert, Pasaniuc Bogdan

Abstract excerpt

BACKGROUND: Although genome-wide association studies have successfully identified thousands of variants associated to complex traits, these variants only explain a small amount of the entire heritability of the trait. Gene-gene interactions have been proposed as a source to explain a significant percentage of the missing heritability. However, detecting gene-gene interactions has proven to be very difficult due...

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Identifiers

PMID: 26498930
DOI: 10.1186/s12863-015-0283-z
PMCID: PMC4619349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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