Article
An ancestry-based approach for detecting interactions.
Genetic epidemiology - 1 Feb 2018
Park Danny S, Eskin Itamar, Kang Eun Yong, Gamazon Eric R, Eng Celeste, Gignoux Christopher R, Galanter Joshua M, Burchard Esteban, Ye Chun J, Aschard Hugues, Eskin Eleazar, Halperin Eran, Zaitlen Noah
Abstract excerpt
BACKGROUND: Epistasis and gene-environment interactions are known to contribute significantly to variation of complex phenotypes in model organisms. However, their identification in human association studies remains challenging for myriad reasons. In the case of epistatic interactions, the large number of potential interacting sets of genes presents computational, multiple hypothesis correction, and other...
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