Article

A targetable dependency on nonsense-mediated decay for proteostasis and immune control in small cell lung cancer

2026-04-02

Abstract excerpt

<h4>Summary</h4> Small cell lung cancer (SCLC) is among the deadliest cancers with excessive somatic alterations, expectedly resulting in immunogenic epitopes. However, patient benefit from immunotherapy is limited. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a hyperactive nonsense-mediated decay (NMD) pathway, responsible for frameshift-mRNA degradation. NMD...

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Literature Corpus work: c133f49c-2f4d-50f5-939d-6747ac537339
DOI: 10.64898/2026.03.31.715503

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