A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer.

doi:10.1186/s12943-026-02750-2

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Article

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer.

Molecular cancer - 27 Aug 2026

Torres-Fernández Lucia A, Boehm Volker, Kaufmann Joel, Becker Jonas P, Garcia-Marquez Maria, de Bruijn Beaunelle, Rumińska Agnieszka, Müller Christian, Bosco Graziella, Alavinejad Nazanin, Lovric Laura, Bihler Johanna I, Schulte Hanna, Davoodi Poorya, Schöllhorn Anna, Weihrauch Kian R, Kaiser Laura, Ibruli Olta, Liu Fanyu, Androulidaki Ariadne, Wobst Nina, Schmiel Marcel, Valiulis Justinas, Maas Lukas, D'Rozario Joshua, Sakthivelu Vignesh, Göbel Bianca, Touet Marian, Brägelmann Johannes, Höpker Katja, John Felix, Wolf Jürgen, Knapp Stefan, Quaas Alexander, Cartolano Maria, von Karstedt Silvia, Beleggia Filippo, Rammensee Hans-Georg, Gouttefangeas Cécile, Schlößer Hans A, Riemer Angelika B, Reinhardt Hans Christian, Gehring Niels H, Peifer Martin, Thomas Roman K, George Julie

Abstract excerpt

Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largely refractory to immunotherapy. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a hyperactive...

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Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nonsense Mediated mRNA Decay

Small Cell Lung Carcinoma

Animals

Lung Neoplasms

Homeostasis

Mice

Cell Line, Tumor

Gene Expression Regulation, Neoplastic

Mutation

Cell Proliferation

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 42711693
DOI: 10.1186/s12943-026-02750-2
PMCID: PMC13551691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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