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Article

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes

1 Apr 2021

Abstract excerpt

Frameshifted protein sequences elicit tumor-specific T cell-mediated immune responses in microsatellite-unstable (MSI) cancers if presented by HLA class I molecules. However, their expression and presentation are limited by nonsense-mediated RNA decay (NMD). We employed an unbiased immunopeptidomics workflow to analyze MSI HCT-116 cells and identified >10,000 HLA class I-presented peptides including five...

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PMID: 33981976
DOI: 10.1016/j.isci.2021.102389

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