Article

Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes

2021-05-31

Abstract excerpt

Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To determine how human cells coordinate mitochondrial and nuclear gene expression processes, we established an optimized ribosome profiling approach tailored for the unique features of the human...

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Literature Corpus work: 68e3bf5d-7c08-5629-bbad-ca6b7fec6090
DOI: 10.1101/2021.05.31.446345

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