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Article

The Diseased Mitoribosome.

FEBS letters - 1 Apr 2021

Ferrari Alberto, Del'Olio Samuel, Barrientos Antoni

Abstract excerpt

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome, a by-product of an ancient endosymbiotic event, mitochondria maintains a specialized and evolutionary divergent protein synthesis machinery, the mitoribosome. Mitoribosome biogenesis depends on elements encoded in both the mitochondrial genome (the RNA components) and the nuclear genome (all ribosomal proteins and...

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Identifiers

PMID: 33314036
DOI: 10.1002/1873-3468.14024
PMCID: PMC8278227

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