Article

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential oncogenic activity

2024-01-09

Abstract excerpt

Simian virus 40 (SV40) is a monkey virus associated with several types of human cancers. SV40 is most frequently detected in mesotheliomas, brain and bone tumors and lymphomas, but the mechanism for SV40 tumorigenesis in humans is not clear. SV40 relative Merkel cell polyomavirus (MCPyV) causes Merkel cell carcinoma (MCC) in humans by expressing truncated large tumor antigen (LT) caused by APOBEC cytidine deaminas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc1b7203-ebae-5920-80ae-1f6a13b57014
DOI: 10.1101/2024.01.09.574829

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential oncogenic activityDOI 10.1101/2024.01.09.574829Read

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity.Semantic proximity Read

Oncogenic Merkel Cell Polyomavirus T Antigen Truncating Mutations are Mediated by APOBEC3 Activity in Merkel Cell Carcinoma.Semantic proximity Read

Emergent Human Pathogen Simian Virus 40 and Its Role in CancerSemantic proximity Read

Cell and Molecular Biology of Simian Virus 40: Implications for Human Infections and DiseaseSemantic proximity Read

Homologous SV40 RNA trans-splicing: a new mechanism for diversification of viral sequences and phenotypes.Semantic proximity Read

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Semantic proximity Read

T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and TumorigenesisSemantic proximity Read

Simian Virus 40 Infection of HumansSemantic proximity Read

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genesSemantic proximity Read

A critical context-dependent role for E boxes in the targeting of somatic hypermutation.Semantic proximity Read

APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.Semantic proximity Read

Constitutive Expression of AID Leads to TumorigenesisSemantic proximity Read