A critical context-dependent role for E boxes in the targeting of somatic hypermutation.

Abstract excerpt

Secondary B cell repertoire diversification occurs by somatic hypermutation (SHM) in germinal centers following Ag stimulation. In SHM, activation-induced cytidine deaminase mutates the V region of the Ig genes to increase the affinity of Abs. Although SHM acts primarily at Ig loci, low levels of off-target mutation can result in oncogenic DNA damage, illustrating the importance of understanding SHM targeting...

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• Share to AICDA (Activation-Induced Cytidine Deaminase)
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