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Article

Oncogenic Merkel Cell Polyomavirus T Antigen Truncating Mutations are Mediated by APOBEC3 Activity in Merkel Cell Carcinoma.

Cancer research communications - 1 Nov 2022

Soikkeli Anni I, Kyläniemi Minna K, Sihto Harri, Alinikula Jukka

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive skin cancer, which is frequently caused by Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major pathologic events of virus-positive (MCPyV+) MCCs, but their source is unclear. Activation-induced cytidine deaminase (AID)/APOBEC family cytidine deaminases contribute to antiviral immunity by mutating viral genomes and are potential...

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Identifiers

PMID: 36970060
DOI: 10.1158/2767-9764.CRC-22-0211
PMCID: PMC10035372

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