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Cell and Molecular Biology of Simian Virus 40: Implications for Human Infections and Disease

20 Jan 1999

Abstract excerpt

Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to millions of people from 1955 through early 1963. SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. This virus has been a favored laboratory model for mechanistic studies of...

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PMID: 9923853
DOI: 10.1093/jnci/91.2.119

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