Article
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.
Scientific reports - 1 Jan 2012
Shinohara Masanobu, Io Katsuhiro, Shindo Keisuke, Matsui Masashi, Sakamoto Takashi, Tada Kohei, Kobayashi Masayuki, Kadowaki Norimitsu, Takaori-Kondo Akifumi
Abstract excerpt
Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobulin (Ig) and non-Ig genes, and aberrant expression of AID leads to tumorigenesis. However, it remains unclear whether...
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