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Article

Homologous SV40 RNA trans-splicing: a new mechanism for diversification of viral sequences and phenotypes.

RNA biology - 1 Nov 2013

Eul Joachim, Patzel Volker

Abstract excerpt

Simian Virus 40 (SV40) is a polyomavirus found in both monkeys and humans, which causes cancer in some animal models. In humans, SV40 has been reported to be associated with cancers but causality has not been proven yet. The transforming activity of SV40 is mainly due to its 94-kD large T antigen, which binds to the retinoblastoma (pRb) and p53 tumor suppressor proteins, and thereby perturbs their functions. Here...

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Identifiers

PMID: 24178438
DOI: 10.4161/rna.26707
PMCID: PMC3907479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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