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T Antigens of Simian Virus 40: Molecular Chaperones for Viral Replication and Tumorigenesis

1 Jun 2002

Abstract excerpt

Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication,...

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PMID: 12040123
DOI: 10.1128/mmbr.66.2.179-202.2002

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