Article

Genetic editing of <i>CISH</i> enhances T cell effector programs independently of immune checkpoint cell surface ligand expression

2021-08-17

Abstract excerpt

<h4>ABSTRACT</h4> PD-1 acts as a negative regulator of T cell-mediated immune responses in the setting of persistent antigen expression, including cancer and chronic pathogen infections. Antibody-mediated blockade of the PD-1/PD-L1 axis benefits a subset of patients with highly immunogenic malignancies; however, many patients fail to respond due to a requirement for expression of the cell surface ligand PD-L1 wit...

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Literature Corpus work: 4591df4c-ad9f-56e9-b773-4dcff14e45bc
DOI: 10.1101/2021.08.17.456714

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