Article

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

2020-09-25

Abstract excerpt

While neoantigen-specific tumor infiltrating lymphocytes (TIL) can be derived from in antigen-expressing tumors, their adoptive transfer fails to consistently elicit durable tumor regression. There has been much focus on the role of activation/exhaustion markers such as PD1, CD39 and TOX in TIL senescence. We found these markers were inversely expressed to Cytokine-Induced SH2 protein (CISH), a negative regulator...

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Literature Corpus work: 2edf8bb5-43b4-5b36-aea0-b3b47814d0d7
DOI: 10.1101/2020.09.24.306571

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