Article

LAG3+ CD8+ T cell Subset Drives HR+/HER2− Breast Cancer Reduction in Bispecific Antibody Armed Activated T Cell Therapy

2025-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Tumor clearance by T cells is impaired by insufficient tumor antigen recognition, insufficient tumor infiltration, and the immunosuppressive tumor microenvironment (TME). Although targeted T cell therapy circumvents failures in tumor antigen recognition, suppression by the TME and failure to infiltrate the tumor can hinder tumor clearance. Checkpoint inhibitors (CPI) promise to reverse T cell su...

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Literature Corpus work: ea1c1e85-afe5-5013-9108-0846c2486c7e
DOI: 10.1101/2025.01.04.631323

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