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Article

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

24 Aug 2022

Abstract excerpt

BACKGROUND: Adoptive transfer of tumor-infiltrating lymphocytes (TIL) fails to consistently elicit tumor rejection. Manipulation of intrinsic factors that inhibit T cell effector function and neoantigen recognition may therefore improve TIL therapy outcomes. We previously identified the cytokine-induced SH2 protein (CISH) as a key regulator of T cell functional avidity in mice. Here, we investigate the...

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Identifiers

PMID: 36007524
DOI: 10.1016/j.medj.2022.07.008

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