Article

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

2020-09-24

Abstract excerpt

<title>Abstract</title> <p>While neoantigen-specific tumor infiltrating lymphocytes (TIL) can be derived from in antigen-expressing tumors, their adoptive transfer fails to consistently elicit durable tumor regression. There has been much focus on the role of activation/exhaustion markers such as PD1, CD39 and TOX in TIL senescence. We found these markers were inversely expressed to Cytokine-Induced SH2 protein (...

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Literature Corpus work: b2eebf52-3a0c-5830-8b4c-7c5ae05ffc75
DOI: 10.21203/rs.3.rs-80800/v1

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