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Article

Integrated Systems Oncology: A Multimodal Framework for Addressing Cancer Heterogeneity

2025-10-08

Abstract excerpt

Cancer represents a complex adaptive system whose therapeutic recalcitrance is fundamentally driven by multidimensional heterogeneity. This heterogeneity manifests across genetic, epigenetic, metabolic, and immune axes, enabling tumors to evolve rapid and robust resistance mechanisms to monotherapies. While targeted therapies and immunotherapies have revolutionized oncology, their efficacy remains constrained by p...

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Identifiers and source

Literature Corpus work
0db286fa-d69b-5384-8306-1d2b53ed0f56
DOI
10.20944/preprints202510.0570.v1
Open publication

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Integrated Systems Oncology: A Multimodal Framework for Addressing Cancer HeterogeneityDOI 10.20944/preprints202510.0570.v1
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