Article
Hereditary prostate cancer - Primetime for genetic testing?
Cancer treatment reviews - 1 Dec 2019
Heidegger Isabel, Tsaur Igor, Borgmann Hendrik, Surcel Christian, Kretschmer Alexander, Mathieu Romain, Visschere Pieter De, Valerio Massimo, van den Bergh Roderick C N, Ost Piet, Tilki Derya, Gandaglia Giorgio, Ploussard Guillaume
Abstract excerpt
Prostate cancer (PCa) remains the most common cancer in men. The proportion of all PCa attributable to high-risk hereditary factors has been estimated to 5-15%. Recent landmark discoveries in PCa genetics led to the identification of germline mutations/alterations (eg. BRCA1, BRCA2, ATM or HOXB13), single nucleotide polymorphisms or copy number variations associated with PCa incidence and progression. However,...
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