Article

Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progression

2024-12-20

Abstract excerpt

Prostate cancer (PC) progresses from benign epithelium through pre-malignant lesions, localized tumors, metastatic dissemination, and castration-resistant stages, with some cases exhibiting phenotype plasticity under therapeutic pressure. However, high-resolution insights into how cell phenotypes evolve across successive stages of PC remain limited. Here, we present the Prostate Cancer Cell Atlas (PCCAT) by integr...

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Literature Corpus work: bc0d9bd4-f97d-5cbc-898d-a3f34f5c9bb5
DOI: 10.1101/2024.12.18.629070

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