Article

SMYD5 is a ribosomal methyltransferase which trimethylates RPL40 lysine 22 through recognition of a KXY motif

2024-10-11

Abstract excerpt

<h4>Summary</h4> The eukaryotic ribosome is highly modified by protein methylation, yet many of the responsible methyltransferases remain unknown. Here we have identified SMYD5 as a ribosomal protein methyltransferase that catalyses trimethylation of RPL40/eL40 at lysine 22. Through a systematic mass spectrometry-based approach, we show that the human ribosome has 12 primary sites of protein methylation, includin...

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Literature Corpus work: bc049397-913d-59b1-a5cb-1e3be0e4d0be
DOI: 10.1101/2024.10.10.616381

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