Article

The human mitochondrial 12S rRNA m <sup>4</sup> C methyltransferase METTL15 is required for proper mitochondrial function

2019-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial DNA (mtDNA) gene expression is coordinately regulated pre- and post-transcriptionally, and its perturbation can lead to human pathologies. Mitochondrial ribosomal RNAs (mt-rRNAs) undergo a series of nucleotide modifications following release from polycistronic mitochondrial RNA (mtRNA) precursors, which is essential for mitochondrial ribosomal biogenesis. Cytosine N 4 methylation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05b67c4d-57a2-5346-af93-f57834c79951
DOI: 10.1101/809756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The human mitochondrial 12S rRNA m <sup>4</sup> C methyltransferase METTL15 is required for proper mitochondrial functionDOI 10.1101/809756Read

The METTL5-TRMT112 <i> N <sup>6</sup> </i> -methyladenosine methyltransferase complex regulates metabolism and development via translationSemantic proximity Read

A late-stage assembly checkpoint of the human mitochondrial ribosome large subunitSemantic proximity Read

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112Semantic proximity Read

TRMT2B is responsible for both tRNA and rRNA m <sup>5</sup> U-methylation in human mitochondriaSemantic proximity Read

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.Semantic proximity Read

Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.Semantic proximity Read

Molecular basis of tRNA modification by the human m <sup>5</sup> C methyltransferase NSUN2Semantic proximity Read

Base-resolution mapping reveals distinct m <sup>1</sup> A methylome in nuclear- and mitochondrial-encoded transcriptsSemantic proximity Read

Human TRMT2A methylates tRNA and contributes to translation fidelitySemantic proximity Read

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.Semantic proximity Read

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesisSemantic proximity Read