Article
From histones to ribosomes: a chromatin regulator tangoes with translation.
Cancer discovery - 1 Mar 2015
Rothbart Scott B, Dickson Bradley M, Strahl Brian D
Abstract excerpt
Histone lysine methylation is a critical regulator of chromatin-templated processes such as gene transcription and DNA repair, and is dynamically controlled by enzymes that write and erase this posttranslational modification. Although histone methylation has been well studied, the functions of no...
Topics
- Antineoplastic Agents
- Drug Resistance, Neoplasm
- Humans
- Jumonji Domain-Containing Histone Demethylases
- Lysine
- Open Reading Frames
- Polymorphism, Single Nucleotide
- Protein Biosynthesis
- Protein Kinase Inhibitors
- TOR Serine-Threonine Kinases