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Article

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes.

Nature communications - 20 May 2024

Wang Lida, Khunsriraksakul Chachrit, Markus Havell, Chen Dieyi, Zhang Fan, Chen Fang, Zhan Xiaowei, Carrel Laura, Liu Dajiang J, Jiang Bibo

Abstract excerpt

Transcriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specific target genes. Single-cell expression quantitative trait loci (sc-eQTL) datasets are emerging. The largest bulk- and sc-eQTL datasets are most conveniently available as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38769300
DOI: 10.1038/s41467-024-48143-1
PMCID: PMC11519974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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