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Article

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

13 Mar 2023

Abstract excerpt

The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles of microglia in AD pathogenesis. Functional deficiencies of TREM2 disrupt microglial clustering around amyloid β (Aβ) plaques, impair their transcriptional response to Aβ, and worsen neuritic dystrophy. However, the molecular mechanism underlying these phenotypes remains unclear. In this study, we...

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Identifiers

PMID: 37035000
DOI: 10.1016/j.isci.2023.106375

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