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INPP5D mRNA Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

2 May 2017

Abstract excerpt

Microglial dysfunction and inflammation have recently been shown to be related to the development of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase (INPP5D) functions broadly as a negative regulator of immune signaling, and its locus was associated with development of AD in a large-scale genome-wide association study. Thus, we examined INPP5D mRNA expression and methylation rates of the CpG sites...

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PMID: 28482637
DOI: 10.3233/jad-161211

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