Article

Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress

2023-04-04

Abstract excerpt

<h4>ABSTRACT</h4> A coordinated oxidative stress response, partly triggered by the transcription factor Nrf2, protects cells from the continual production of reactive oxygen species. Left unbuffered, reactive oxygen species can lead to protein aggregation which has been implicated in a spectrum of diseases including cataract of the ocular lens and myopathy of the heart. While proteostasis is maintained by diverse...

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Literature Corpus work: bbd015bb-20d8-5a22-a9ba-bbf42e69580e
DOI: 10.1101/2023.04.04.535454

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