Article

Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens

2024-01-04

Abstract excerpt

The vertebrate eye lens is an unusual organ in that most of its cells lack nuclei and the ability to replace aging protein. The small heat shock protein α-crystallins evolved to become key components of this lens, possibly because of their ability to prevent aggregation of aging protein that would otherwise lead to lens opacity. Most vertebrates express two α-crystallins, αA- and αB-crystallin, and mutations in ea...

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Literature Corpus work: 628db73e-0057-53f0-83d3-16178170dc26
DOI: 10.1101/2024.01.03.574085

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