Article

Upregulation of the Unfolded and Mitochondrial Unfolded Protein Responses in Oxidative Stress-Induced Cataract

2026-08-20

Abstract excerpt

<h4>Purpose: </h4> Oxidative stress is thought to contribute to the development of age-related cataracts (ARCs), but the mechanisms by which oxidative damage leads to the opacification of the lens remain unclear. Previous studies suggest that oxidative stress can disrupt lens proteostasis. Therefore, it was hypothesized that ARCs arise from proteomic changes driven by an age-associated decline in oxidative stress...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b5274ae-91a7-51d7-b763-7c7d24db9929
DOI: 10.64898/2026.08.19.745850

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Upregulation of the Unfolded and Mitochondrial Unfolded Protein Responses in Oxidative Stress-Induced CataractDOI 10.64898/2026.08.19.745850Read

Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stressSemantic proximity Read

Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts.Semantic proximity Read

JAG1/Notch Pathway Inhibition Induces Ferroptosis and Promotes CataractogenesisSemantic proximity Read

Cataract Review of Integrating Pathogenic Mechanisms, Experimental Models, and Therapeutic DevelopmentSemantic proximity Read

Lens ER-stress response during cataract development in Mip-mutant mice.Semantic proximity Read

Cataract-causing allele in CRYAA (Y118D) proceeds through endoplasmic reticulum stress in mouse model.Semantic proximity Read

Redox Regulation in Age-Related Cataracts: Roles for Glutathione, Vitamin C, and the NRF2 Signaling PathwaySemantic proximity Read

Proteomic characterization of the human lens and CataractogenesisSemantic proximity Read

Proteostasis in aging-associated ocular diseaseSemantic proximity Read

Cataract in the human lens: a systematic review of proteomic studiesSemantic proximity Read

Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice.Semantic proximity Read

Slit2 Promotes H 2 O 2 -Induced Lens Epithelial Cells Oxidative Damage and Age-Related CataractSemantic proximity Read