Article
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Antioxidants & redox signaling - 15 Mar 2011
Rajasekaran Namakkal Soorappan, Varadharaj Saradhadevi, Khanderao Gayatri D, Davidson Christopher J, Kannan Sankaranarayanan, Firpo Matthew A, Zweier Jay L, Benjamin Ivor J
Abstract excerpt
Inheritable missense mutations in small molecular weight heat-shock proteins (HSP) with chaperone-like properties promote self-oligomerization, protein aggregation, and pathologic states such as hypertrophic cardiomyopathy in humans. We recently described that human mutant αB-crystallin (hR120GCryAB) overexpression that caused protein aggregation cardiomyopathy (PAC) was genetically linked to dysregulation of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.