Article

Early Transcriptomic Signatures of Reductive Stress Cardiomyopathy Reveal Insufficient HIF-1α Signaling

2025-09-01

Abstract excerpt

Chronic activation of Nrf2-regulated antioxidant pathways can lead to a pathological condition known as reductive stress (RS). While transient Nrf2 activation confers protection against oxidative stress, its sustained stimulation may provoke maladaptive responses in high-energy-demanding organs such as the heart. In this study, we employed a cardiac-specific constitutively active Nrf2 transgenic (CaNrf2-TG) mouse...

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Literature Corpus work: 62c904a5-d311-5fb0-85e0-96bbaf9a9e8d
DOI: 10.1101/2025.09.01.672999

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