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Article

Lens ER-stress response during cataract development in Mip-mutant mice.

Biochimica et biophysica acta - 1 Aug 2016

Zhou Yuefang, Bennett Thomas M, Shiels Alan

Abstract excerpt

Major intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role in establishing lens fiber cell architecture. Genetic variants of MIP have been associated with inherited and age-related forms of cataract; however, the underlying pathogenic mechanisms are unclear. Here we have used lens transcriptome profiling by microarray-hybridization and qPCR to identify pathogenic changes during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27155571
DOI: 10.1016/j.bbadis.2016.05.003
PMCID: PMC4885755

Genes

MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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