The unfolded protein response is activated in connexin 50 mutant mouse lenses.

Abstract excerpt

The unfolded protein response is a set of cell signaling pathways recently recognized to be activated in the lens during both normal development and endoplasmic reticulum stress induced by either unfolded proteins or oxidative damage. While mutations in the gene for connexin 50 are known to cause autosomal dominant cataracts, it has not been previously reported whether mutant connexins can activate the unfolded...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to X-Box Binding Protein 1
• Share to Activating Transcription Factor 4