Article

Increased Autotaxin levels in severe COVID-19, correlating with IL-6 levels, endothelial dysfunction biomarkers, and impaired functions of dendritic cells

2021-07-31

Abstract excerpt

Autotaxin (ATX; ENPP2 ) is a secreted lysophospholipase D catalysing the extracellular production of lysophosphatidic acid (LPA), a pleiotropic signalling phospholipid. Genetic and pharmacologic studies have previously established a pathologic role for ATX and LPA signalling in pulmonary injury, inflammation, and fibrosis. Here, increased ENPP2 mRNA levels were detected in immune cells from nasopharyngeal swab sam...

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Literature Corpus work: 4efad17f-5017-57a2-9fa9-278b5f0d97fa
DOI: 10.1101/2021.07.30.21261361

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