Article

GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early-onset Tay-Sachs disease.

2020-03-31

Abstract excerpt

<title>Abstract</title> <p>Background Tay-Sachs disease (TSD), a type of GM2-gangliosidosis, is a progressive neurodegenerative lysosomal storage disorder; caused by mutations in the a subunit of the lysosomal β-hexosaminidase enzyme. This disease is characterized by excessive accumulation of GM2 ganglioside, predominantly in the central nervous system. Although Tay-Sachs patients appear normal at birth, the prog...

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Literature Corpus work: 4e3af3ef-a06c-56f4-beba-440cff9f9f2b
DOI: 10.21203/rs.2.20299/v2

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