Article

Lysophosphatidic acid receptor 1 influences disease severity in a mouse model of multiple sclerosis

2024-06-02

Abstract excerpt

Multiple sclerosis (MS), a chronic inflammatory disease affecting the central nervous system (CNS), is characterized by demyelination and axonal degeneration. Current treatments, which focus mainly on reducing lymphocyte infiltration into the CNS, are insufficient due to serious side effects and limited effectiveness; thus, identifying drugs with new mechanisms of action is crucial. Lysophosphatidic acid (LPA), a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5207a2a0-d908-5cdb-b798-826e475bfe0a
DOI: 10.1101/2024.05.28.596148

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lysophosphatidic acid receptor 1 influences disease severity in a mouse model of multiple sclerosisDOI 10.1101/2024.05.28.596148Read

Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.Semantic proximity Read

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesisSemantic proximity Read

Inhibition of lysophosphatidic acid receptor 1-3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stressSemantic proximity Read

Genetic deletion of Autotaxin from CD11b <sup>+</sup> cells decreases the severity of experimental autoimmune encephalomyelitisSemantic proximity Read

A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.Semantic proximity Read

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.Semantic proximity Read

Pathogenic inflammation in the CNS of mice carrying human PLP1 mutations.Semantic proximity Read

Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.Semantic proximity Read

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.Semantic proximity Read

Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus.Semantic proximity Read

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-Like Receptor 4 in MicrogliaSemantic proximity Read

Activation of central cannabinoid type 2 receptors, but not on peripheral immune cells, is required for endocannabinoid-mediated neuroprotection in Parkinson´s diseaseSemantic proximity Read