Article

NRF2 co-opts the SWI/SNF complex to drive liver cell plasticity

2026-02-11

Abstract excerpt

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a role in the regulation of redox homeostasis and cellular metabolism. Activating mutations in the NRF2 pathway have been identified in approximately 15% of liver cancer patients. However, the mechanisms by which NRF2 promotes liver tumorigenesis are poorly understood. Employing a transgenic zebrafish model with hepatocyte-spec...

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Literature Corpus work: b40bc0dd-4fe3-553a-8960-69f4656c6f54
DOI: 10.64898/2026.02.09.704724

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