Article
Nuclear factor erythroid 2-related factor 2 and β-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications.
Hepatology (Baltimore, Md.) - 1 Aug 2021
Tao Junyan, Krutsenko Yekaterina, Moghe Akshata, Singh Sucha, Poddar Minakshi, Bell Aaron, Oertel Michael, Singhi Aatur D, Geller David, Chen Xin, Lujambio Amaia, Liu Silvia, Monga Satdarshan P
Abstract excerpt
BACKGROUND AND AIMS: HCC remains a major unmet clinical need. Although activating catenin beta-1 (CTNNB1) mutations are observed in prominent subsets of HCC cases, these by themselves are insufficient for hepatocarcinogenesis. Coexpression of mutant CTNNB1 with clinically relevant co-occurrence has yielded HCCs. Here, we identify cooperation between β-catenin and nuclear factor erythroid 2-related factor 2 (Nrf2)...
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