Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.

Journal of hepatology - 1 Dec 2014

Eichenmüller Melanie, Trippel Franziska, Kreuder Michaela, Beck Alexander, Schwarzmayr Thomas, Häberle Beate, Cairo Stefano, Leuschner Ivo, von Schweinitz Dietrich, Strom Tim M, Kappler Roland

Abstract excerpt

BACKGROUND & AIMS: Hepatoblastoma (HB) is the most common childhood liver cancer and occasionally presents with histological and clinical features reminiscent of hepatocellular carcinoma (HCC). Identification of molecular mechanisms that drive the neoplastic continuation towards more aggressive HCC phenotypes may help to guide the new stage of targeted therapies. METHODS: We performed comprehensive studies on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Hepatoblastoma

Share to Kelch-Like ECH-Associated Protein 1

Share to Liver Neoplasms

Share to NF-E2-Related Factor 2

Share to Telomerase

Source

Identifiers

PMID: 25135868
DOI: 10.1016/j.jhep.2014.08.009

Genes

CTNNB1
KEAP1
TERT
CUL3
NQO1
RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.PMID 25135868Read ↗

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.Semantic proximity Read ↗

Molecular Profiling of a Hepatocellular Neoplasm Not Otherwise Specified (HCN-NOS) Demonstrates Distinct Molecular Features in Hepatoblastoma and HCC-Like Components.Semantic proximity Read ↗

Landscape of Somatic Alterations in Thai Pediatric Hepatoblastoma: Implications for Clinical Outcomes and Therapeutic Opportunities.Semantic proximity Read ↗

Comparative Clinicopathologic and Genomic Analysis of Hepatocellular Neoplasm, Not Otherwise Specified, and HepatoblastomaSemantic proximity Read ↗

Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict hepatoblastoma survival.Semantic proximity Read ↗

Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implicationsSemantic proximity Read ↗

Novel CTNNB1 gene mutations reveal critical pathogenic mechanisms in pediatric hepatoblastomaSemantic proximity Read ↗

Genomic landscape of hepatocarcinogenesis.Semantic proximity Read ↗

Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targetsSemantic proximity Read ↗

General paucity of genomic alteration and low tumor mutation burden in refractory and metastatic hepatoblastoma: comprehensive genomic profiling study.Semantic proximity Read ↗

Comprehensive allelotyping of hepatoblastoma.Semantic proximity Read ↗

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine HepatoblastomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.