Article

Gut bacterial Infection drives Parkinsonian pathology in LRRK2 G2019S Knock-in Mice

2026-06-10

Abstract excerpt

The LRRK2 G2019S mutation is one of the most common genetic risk factors for Parkinson’s disease (PD), yet LRRK2 G2019S knock-in (KI) mice rarely develop robust neurodegeneration under basal conditions, suggesting that additional environmental triggers are required for disease progression. Here, we established a clinically relevant gene–environment interaction mouse model of PD by subjecting LRRK2 G2019S KI mice t...

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Literature Corpus work: cc55ab33-4d02-57e8-b81b-cb374d19ad8d
DOI: 10.64898/2026.06.08.728789

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