Article

Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn’s Disease-Linked LRRK2-N2081D Variant

2024-09-05

Abstract excerpt

LRRK2 contains a kinase domain where both the N2081D Crohn’s disease (CD) risk and the G2019S Parkinson’s disease (PD)-pathogenic variants are located. The mechanisms by which the N2081D variant increase CD risk, and how these adjacent mutations result in distinct diseases, remain unclear. To investigate the pathophysiology of the CD-linked LRRK2 N2081D variant, we generated a knock-in (KI) mouse model and compare...

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Literature Corpus work: c767e26e-abd0-5f8c-953a-af2e60a13266
DOI: 10.1101/2024.09.05.611530

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